High‐frequency deep brain stimulation of the putamen improves bradykinesia in Parkinson's disease
Identifieur interne : 000299 ( Main/Exploration ); précédent : 000298; suivant : 000300High‐frequency deep brain stimulation of the putamen improves bradykinesia in Parkinson's disease
Auteurs : Erwin B. Montgomery Jr. [États-Unis] ; He Huang [États-Unis] ; Harrison C. Walker [États-Unis] ; Barton L. Guthrie [États-Unis] ; Ray L. Watts [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-10.
English descriptors
Abstract
Deep brain stimulation is effective for a wide range of neurological disorders; however, its mechanisms of action remain unclear. With respect to Parkinson's disease, the existence of multiple effective targets suggests that putamen stimulation also may be effective and raises questions as to the mechanisms of action. Are there as many mechanisms of action as there are effective targets or some single or small set of mechanisms common to all effective targets? During the course of routine surgery of the globus pallidus interna in patients with Parkinson's disease, the deep brain stimulation lead was placed in the putamen en route to the globus pallidus interna. Recordings of hand opening and closing during high‐frequency and no stimulation were made. Speed of the movements, based on the amplitude and frequency of the repetitive hand movements as well as the decay in amplitude, were studied. Hand speed in 6 subjects was statistically significantly faster during active deep brain stimulation than the no‐stimulation condition. There were no statistically significant differences in decay in the amplitude of hand movements. High‐frequency deep brain stimulation of the putamen improves bradykinesia in a hand‐opening and ‐closing task in patients with Parkinson's disease. Consequently, high‐frequency deep brain stimulation of virtually every structure in the basal ganglia‐thalamic‐cortical system improves bradykinesia. These observations, together with microelectrode recordings reported in the literature, argue that deep brain stimulation effects may be system specific and not structure specific. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23842
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">High‐frequency deep brain stimulation of the putamen improves bradykinesia in Parkinson's disease</title><author><name sortKey="Montgomery Jr, Erwin B" sort="Montgomery Jr, Erwin B" uniqKey="Montgomery Jr E" first="Erwin B." last="Montgomery Jr.">Erwin B. Montgomery Jr.</name></author><author><name sortKey="Huang, He" sort="Huang, He" uniqKey="Huang H" first="He" last="Huang">He Huang</name></author><author><name sortKey="Walker, Harrison C" sort="Walker, Harrison C" uniqKey="Walker H" first="Harrison C." last="Walker">Harrison C. Walker</name></author><author><name sortKey="Guthrie, Barton L" sort="Guthrie, Barton L" uniqKey="Guthrie B" first="Barton L." last="Guthrie">Barton L. Guthrie</name></author><author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L." last="Watts">Ray L. Watts</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:49F70A17C7815F69D4C258A31B019E171A6594D3</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23842</idno><idno type="url">https://api.istex.fr/document/49F70A17C7815F69D4C258A31B019E171A6594D3/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001B67</idno><idno type="wicri:Area/Main/Curation">001901</idno><idno type="wicri:Area/Main/Exploration">000299</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">High‐frequency deep brain stimulation of the putamen improves bradykinesia in Parkinson's disease</title><author><name sortKey="Montgomery Jr, Erwin B" sort="Montgomery Jr, Erwin B" uniqKey="Montgomery Jr E" first="Erwin B." last="Montgomery Jr.">Erwin B. Montgomery Jr.</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Huang, He" sort="Huang, He" uniqKey="Huang H" first="He" last="Huang">He Huang</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Walker, Harrison C" sort="Walker, Harrison C" uniqKey="Walker H" first="Harrison C." last="Walker">Harrison C. Walker</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Guthrie, Barton L" sort="Guthrie, Barton L" uniqKey="Guthrie B" first="Barton L." last="Guthrie">Barton L. Guthrie</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L." last="Watts">Ray L. Watts</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-10">2011-10</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2232">2232</biblScope><biblScope unit="page" to="2238">2238</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">49F70A17C7815F69D4C258A31B019E171A6594D3</idno><idno type="DOI">10.1002/mds.23842</idno><idno type="ArticleID">MDS23842</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>bradykinesia</term><term>deep brain stimulation</term><term>pathophysiology</term><term>physiology</term><term>putamen</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation is effective for a wide range of neurological disorders; however, its mechanisms of action remain unclear. With respect to Parkinson's disease, the existence of multiple effective targets suggests that putamen stimulation also may be effective and raises questions as to the mechanisms of action. Are there as many mechanisms of action as there are effective targets or some single or small set of mechanisms common to all effective targets? During the course of routine surgery of the globus pallidus interna in patients with Parkinson's disease, the deep brain stimulation lead was placed in the putamen en route to the globus pallidus interna. Recordings of hand opening and closing during high‐frequency and no stimulation were made. Speed of the movements, based on the amplitude and frequency of the repetitive hand movements as well as the decay in amplitude, were studied. Hand speed in 6 subjects was statistically significantly faster during active deep brain stimulation than the no‐stimulation condition. There were no statistically significant differences in decay in the amplitude of hand movements. High‐frequency deep brain stimulation of the putamen improves bradykinesia in a hand‐opening and ‐closing task in patients with Parkinson's disease. Consequently, high‐frequency deep brain stimulation of virtually every structure in the basal ganglia‐thalamic‐cortical system improves bradykinesia. These observations, together with microelectrode recordings reported in the literature, argue that deep brain stimulation effects may be system specific and not structure specific. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Alabama</li></region></list><tree><country name="États-Unis"><region name="Alabama"><name sortKey="Montgomery Jr, Erwin B" sort="Montgomery Jr, Erwin B" uniqKey="Montgomery Jr E" first="Erwin B." last="Montgomery Jr.">Erwin B. Montgomery Jr.</name></region><name sortKey="Guthrie, Barton L" sort="Guthrie, Barton L" uniqKey="Guthrie B" first="Barton L." last="Guthrie">Barton L. Guthrie</name><name sortKey="Huang, He" sort="Huang, He" uniqKey="Huang H" first="He" last="Huang">He Huang</name><name sortKey="Walker, Harrison C" sort="Walker, Harrison C" uniqKey="Walker H" first="Harrison C." last="Walker">Harrison C. Walker</name><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L." last="Watts">Ray L. Watts</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000299 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000299 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:49F70A17C7815F69D4C258A31B019E171A6594D3
|texte= High‐frequency deep brain stimulation of the putamen improves bradykinesia in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |